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Plasma Exchange in Chronic Progressive Multiple Sclerosis:A Long-Term Study Neurol 41:409-414, Khatri,B.O.,et al, 1991 See this aricle in Pubmed Article Abstract Plasma exchange(PE)was shown in a previous double-blind randomized controlled study to confer significant additional benefit at 1 year upon patients with chronic progressive multiple sclerosis(CPMS)treated with immunosuppressive drug therapy(ISDT).Efficacy over an extended term, indications for retreatment,and long-term toxicity are dealt with in this analysis of a larger number of patients.During the past 7 years,200 patients with CPMS have been treated with PE and low-dose ISDT at this center.Improvement on the Kurtzke Disability Status Scale by one or more steps post-therapy and at 3-year follow-up is significant by comparison with pre-PE disability status.Clinical improvement was maintained in the majority of patients,reaching as far as a 6-year follow-up.Major life- threatening complications attributable to this combined therapy were not observed.

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(click to filter results - removes previous filter) immunosuppressive agents multiple sclerosis multiple sclerosis,chronic progressive multiple sclerosis,treatment of plasmapheresis

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